C6305

Clozapine

• 동의어(들): 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
• 실험식(Hill 표기법): C₁₈H₁₉ClN₄
• CAS Number: 5786-21-0
• Molecular Weight: 326.82
• MDL number: MFCD00153785
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277892
• NACRES: NA.77

속성

• 형태: powder
• Quality Level: 300
• solubility: ethanol: 1 mg/mL; 0.1 M HCl: 30 mg/mL; DMSO: 4.8 mg/mL
• 주관자: Novartis
• SMILES string: CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA1A(148) , ADRA2A(150) , ADRA2C(152) , CHRM1(1128) , DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HRH4(59340) , HTR2A(3356) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR6(3362) , HTR7(3363) , KCNH1(3756) , KCNH2(3757) , UGT1A4(54657) ; rat ... Adra1a(29412) , Adra2a(25083) , Adrb1(24925) , Chrm1(25229) , Drd1a(24316) , Drd2(24318) , Drd3(29238) , Drd4(25432) , Hrh1(24448) , Htr1a(24473) , Htr1b(25075) , Htr2a(29595) , Htr2b(29581) , Htr2c(25187) , Htr3a(79246) , Htr7(65032) , Slc6a4(25553)

설명

생화학적/생리학적 작용

Atypical antipsychotic compound. Selective antagonist for D₄-dopamine receptor. Antagonist at 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₆, and 5-HT₇ serotonin receptors.

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable