C0737

Cilostazol

≥98% (HPLC), powder

• 동의어(들): 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal
• 실험식(Hill 표기법): C₂₀H₂₇N₅O₂
• CAS Number: 73963-72-1
• Molecular Weight: 369.46
• MDL number: MFCD00866780
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24278291
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white
• solubility: DMSO: 10 mg/mL, clear
• 주관자: Otsuka Pharma
• SMILES string: O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1
• InChI: 1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
• InChI key: RRGUKTPIGVIEKM-UHFFFAOYSA-N
• 유전자 정보: human ... PDE3A(5139) , PDE3B(5140)

설명

일반 설명

Cilostazol prevents platelet aggregation and has vasodilatory properties. It is used to treat chronic arterial disease and intermittent claudication. Cilostazol has antiproliferative effects and improves the properties of prostacyclin. It regulates cell proliferation, stimulates cyclic adenosine monophosphate (cAMP) level and induces cyclic AMP-dependent protein kinase.

애플리케이션

Cilostazol has been used:

• to reduce Madin–Darby cell line (MDCK) proliferation through c-Myc down-regulation
• in the in vitro assessment of toxin delivery in T84 intestinal epithelial cells
• to induce adenosine triphosphate (ATP) release in white adipocytes

생화학적/생리학적 작용

Phosphodiesterase III (PDE3) inhibitor

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Otsuka Pharma. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361d
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)