C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• 동의어(들): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• 실험식(Hill 표기법): C₂₁H₃₀O₄
• CAS Number: 50-22-6
• Molecular Weight: 346.46
• Beilstein: 2339601
• EC Number: 200-019-6
• MDL number: MFCD00037715
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278302
• NACRES: NA.77

속성

• product name: Corticosterone, ≥92%
• 생물학적 소스: synthetic (organic)
• 분석: ≥92%
• 형태: powder
• mp: 179-183 °C (lit.)
• solubility: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• 유전자 정보: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

설명

애플리케이션

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

생화학적/생리학적 작용

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves