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Merck
모든 사진(1)

주요 문서

A4941

Sigma-Aldrich

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

동의어(들):

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

EC Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32

제품명

Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

생물학적 소스

human

Quality Level

재조합

expressed in baculovirus infected insect cells

분석

≥95% (SDS-PAGE)

양식

lyophilized powder

효능

1-10 ng/mL ED50

분자량

dimer 26 kDa (containing 116 amino acid residues βA subunits)

포장

pkg of 10 μg
pkg of 5 μg

기술

cell culture | mammalian: suitable

불순물

endotoxin, tested

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... INHBA(3624)

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일반 설명

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

애플리케이션

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

생화학적/생리학적 작용

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

물리적 형태

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

분석 메모

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Erythroid differentiation bioassays for activin.
R H Schwall et al.
Methods in enzymology, 198, 340-346 (1991-01-01)

문서

Naive pluripotent stem cells are located within the epiblast of mature blastocysts. These primitive “ground-state” cells may be cultured in vitro using specialized media and small molecule inhibitors.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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