X3004

XAV939

≥98% (HPLC), powder, tankyrase inhibitor

• 동의어(들): 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
• 실험식(Hill 표기법): C₁₄H₁₁F₃N₂OS
• CAS Number: 284028-89-3
• Molecular Weight: 312.31
• MDL number: MFCD16879017
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329830802
• NACRES: NA.77

속성

• product name: XAV939, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear
• 저장 온도: room temp
• SMILES string: FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
• InChI: 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
• InChI key: KLGQSVMIPOVQAX-UHFFFAOYSA-N

설명

애플리케이션

XAV939 has been used in the inhibition

• of tankyrase in neuroblastoma cell lines
• of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
• of wnt signalling in human induced pluripotent stem cells (hiPSCs)

생화학적/생리학적 작용

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

기타 정보

XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable