S4317

SB 431542 hydrate

≥98% (HPLC), powder, inhibits activation of SMAD proteins

• 동의어(들): 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• 실험식(Hill 표기법): C₂₂H₁₆N₄O₃ · xH₂O
• CAS Number: 301836-41-9
• Molecular Weight: 384.39 (anhydrous basis)
• MDL number: MFCD11045982
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24724609
• NACRES: NA.77

속성

• product name: SB 431542 hydrate, ≥98% (HPLC), powder
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• solubility: DMSO: soluble 10 mg/mL; H₂O: insoluble
• 주관자: GlaxoSmithKline
• 저장 온도: −20°C
• SMILES string: O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
• InChI: 1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
• InChI key: WQUIJVKNPYBZOF-UHFFFAOYSA-N

설명

애플리케이션

SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells. It was used to study the role of TGF-β signaling in modulation of extracellular matrix and myoblast differentiation.

생화학적/생리학적 작용

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.

특징 및 장점

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from Glaxo­Smith­Kline

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)