30960

Deoxycholic acid

≥99.0% (T)

• 동의어(들): 3α,12α-Dihydroxy-5β-cholanic acid, 7-Deoxycholic acid, Desoxycholic acid
• 실험식(Hill 표기법): C₂₄H₄₀O₄
• CAS Number: 83-44-3
• Molecular Weight: 392.57
• Beilstein: 3219882
• EC Number: 201-478-5
• MDL number: MFCD00003673
• UNSPSC 코드: 12352106
• PubChem Substance ID: 329753610
• NACRES: NA.77

속성

• 생물학적 소스: ox bile
• Quality Level: 100
• 설명: anionic
• 분석: ≥99.0% (T)
• 형태: powder
• 광학 활성: [α]20/D +54±1°, c = 1% in ethanol
• 분자량: 392.57 g/mol
• 불순물: ≤1% cholic acid (TLC)
• mp: 170-175 °C; 171-174 °C (lit.)
• 작용기: carboxylic acid
• SMILES string: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
• InChI: 1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
• InChI key: KXGVEGMKQFWNSR-LLQZFEROSA-N
• 유전자 정보: human ... ATIC(471)

설명

일반 설명

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.

애플리케이션

Deoxycholic acid has been used as:

• a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
• an internal standard to estimate the toxin concentration in the cell pellet
• a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

생화학적/생리학적 작용

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.

기타 정보

For the solubilization of the β-adrenergic receptor

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves