Y0001761

Nicorandil

European Pharmacopoeia (EP) Reference Standard

• 동의어(들): 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• 실험식(Hill 표기법): C₈H₉N₃O₄
• CAS Number: 65141-46-0
• Molecular Weight: 211.17
• MDL number: MFCD00186520
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329831558
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: nicorandil
• 제조업체/상표: EDQM
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: −20°C
• SMILES string: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• InChI key: LBHIOVVIQHSOQN-UHFFFAOYSA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

생화학적/생리학적 작용

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H242,H302
• 예방조치 성명서: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Hazard Classifications: Acute Tox. 4 Oral - Org. Perox. D
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable