90221

Retigabine

analytical standard

• 동의어(들): D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
• 실험식(Hill 표기법): C₁₆H₁₈FN₃O₂
• CAS Number: 150812-12-7
• Molecular Weight: 303.33
• Beilstein: 8072099
• MDL number: MFCD04307735
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329769861
• NACRES: NA.24

속성

• Grade: analytical standard
• Quality Level: 100
• 분석: ≥98.0% (HPLC)
• 유통기한: limited shelf life, expiry date on the label
• 약물 제어: USDEA Schedule IV
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 불순물: ≤1.0% water (calc. from elemental analysis)
• 응용 분야: forensics and toxicology; veterinary
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
• InChI: 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
• InChI key: PCOBBVZJEWWZFR-UHFFFAOYSA-N
• 유전자 정보: human ... KCNQ1(3784) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479)

설명

일반 설명

Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.

애플리케이션

Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).

생화학적/생리학적 작용

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H331 - H410
• 예방조치 성명서: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable