29208
(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide
for protein sequence analysis (by MALDI-MS), ≥98.5%
동의어(들):
N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide, TMPP-Ac-OSu
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C33H39BrNO13P
CAS Number:
Molecular Weight:
768.54
MDL number:
UNSPSC 코드:
41116105
PubChem Substance ID:
NACRES:
NA.21
추천 제품
Grade
for protein sequence analysis (by MALDI-MS)
Quality Level
분석
≥98.5% (HPLC)
≥98.5%
기술
MALDI-MS: suitable
mp
199-205 °C (dec.)
저장 온도
−20°C
SMILES string
[Br-].COc1cc(OC)c(c(OC)c1)[P+](CC(=O)ON2C(=O)CCC2=O)(c3c(OC)cc(OC)cc3OC)c4c(OC)cc(OC)cc4OC
InChI
1S/C33H39NO13P.BrH/c1-38-19-12-22(41-4)31(23(13-19)42-5)48(18-30(37)47-34-28(35)10-11-29(34)36,32-24(43-6)14-20(39-2)15-25(32)44-7)33-26(45-8)16-21(40-3)17-27(33)46-9;/h12-17H,10-11,18H2,1-9H3;1H/q+1;/p-1
InChI key
YKMSQZIYVKTUHI-UHFFFAOYSA-M
일반 설명
N-Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP-Ac-OSu) is an acylating reagent, and is generally used for the selective derivatization of N-terminal a-amino group of peptide. The TMPP-acetylated peptides undergo fragmentation thereby creating a-type ions, thus obtaining sequence information becomes easier, even without the usage of automated computational approach. It can be used as a labelling reagent in liquid chromatography-coupled mass spectrometry (LC-MS/MS) of N-terminal peptides, so as to improve ionization efficiency, simplify fragmentation, and retention times, thereby leading to better separation of peptides.
애플리케이션
TMPP-Ac-OSu was used for labelling peptides, in tandem mass spectrometry, done for converting arginine to ornithine, in order to improve the fragmentation pattern of peptides.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
기타 정보
Reagent for modifying N-termial of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS
관련 제품
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Z. Huang et al.
Analytical Biochemistry, 69, 137-137 (1997)
Z H Huang et al.
Analytical biochemistry, 268(2), 305-317 (1999-03-17)
We have recently reported a simple procedure by which low picomole quantities of peptides can be modified to the corresponding N-Tris(2, 4,6-trimethoxyphenyl)phosphonium-acetyl (TMPP-Ac) derivatives (Z. H Huang, J. Wu, D. A. Gage, and J. T. Watson, Anal. Chem. 69, 137-144
Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.
Gallien S
Genome Research, 19 (1), 128-135 (2009)
Conversion of arginine to ornithine for improving the fragmentation pattern of peptides labeled with the N-terminal tris (2, 4, 6-trimethoxyphenyl) phosphonium group in tandem mass spectrometry.
Kuyama H
Analytical Methods : Advancing Methods and Applications, 2 (11), 1792-1797 (2010)
M Lisa Manier et al.
Journal of mass spectrometry : JMS, 49(8), 665-673 (2014-07-22)
Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical challenges. Since analytical tissue blanks do not exist for endogenous metabolites, careful consideration must be given to confirm molecular identity. Here, we
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