8.51221

PyAOP

for peptide synthesis, Novabiochem^®

• 동의어(들): PyAOP, (7-Azabenzotriazol-1-yloxy)trispyrrolidinophosphonium hexafluorophosphate
• 실험식(Hill 표기법): C₁₇H₂₇F₆N₇OP₂
• CAS Number: 156311-83-0
• Molecular Weight: 521.38
• MDL number: MFCD03703417
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• 제품명: PyAOP, Novabiochem^®
• Quality Level: 200
• 제품 라인: Novabiochem^®
• 양식: powder
• 반응 적합성: reaction type: Coupling Reactions
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 저장 온도: 15-25°C
• SMILES string: F[P-](F)(F)(F)(F)F.[P](=[N+]5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1nccc2
• InChI: 1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
• InChI key: CBZAHNDHLWAZQC-UHFFFAOYSA-N

설명

일반 설명

PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references:
^[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.

애플리케이션

PyAOP can be used as a coupling reagent:

• In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
• To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.

분석 메모

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315 - H319 - H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable