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Merck
모든 사진(1)

주요 문서

27285

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

동의어(들):

Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

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About This Item

실험식(Hill 표기법):
C10H14N2Na2O8 · 2H2O
CAS Number:
Molecular Weight:
372.24
Beilstein:
3900609
EC Number:
UNSPSC 코드:
12352107
PubChem Substance ID:
NACRES:
NA.77

Agency

tested according to BP
tested according to Ph. Eur.
tested according to USP

Quality Level

규정 준수

tested according to FCC

분석

99.0-101.0%

양식

crystals

품질

meets analytical specification of Ph. Eur., BP, USP, FCC

반응 적합성

reagent type: chelator

불순물

residual solvents, complies
≤0.001% cyanide (CN)
≤0.001% heavy metals (as Pb)
≤0.1% nitrilotriacetic acid (HPLC) (HPLC)

손실

8.7-11.4% loss on drying, 200 °C, 3 h

pH

4-5 (20 °C, 5%)

mp

248 °C (dec.) (lit.)

solubility

water: soluble 100 g/L at 20 °C

음이온 미량물

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

양이온 미량물

As: ≤1 mg/kg
Ca:, in accordance
Fe: ≤10 mg/kg
Pb: ≤10 mg/kg

응용 분야

pharmaceutical (small molecule)

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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일반 설명

Ethylenediaminetetraacetic acid disodium salt dihydrate, referred to as EDTA is a widely used chelator of divalent cations like Ca⁺². It can inhibit proteases dependent on metal ions, such as, calcium-dependent cysteine proteases. EDTA also acts as a chelator of the Zn ion, inhibiting metalloproteases that require zinc for activity.

애플리케이션

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

기타 정보

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픽토그램

Health hazardExclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

표적 기관

Respiratory Tract

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Evaluation of EDTA as the chelator in the biuret reagent.
H Van Kley et al.
Clinical chemistry, 19(6), 621-623 (1973-06-01)
Haruthai Sangjarusvichai et al.
Talanta, 79(4), 1036-1041 (2009-07-21)
In this report, we aimed to extend our previous efforts toward the evaluation of sulfonamides (SAs) with a boron-doped diamond (BDD) electrode. We improved this method by reducing the analysis time using a monolithic column coupled with amperometric detection to
Sinan Akbayram et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(5), 494-496 (2010-06-10)
Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent PTCP is usually prevented by other anticoagulants
Solvent-free hydrothermal synthesis of anatase TiO2nanoparticleswith enhanced photocatalytic hydrogen production activity.
Ayad F. Alkaim
Applied Catalysis A: General, 466, 32- 37 (2013)
Suli Huang et al.
PloS one, 10(2), e0117007-e0117007 (2015-02-07)
microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms in miRNA genes may contribute to disease susceptibility. However, the effect of miR-146a, miR-196a2, and miR-499 polymorphisms on ischemic stroke susceptibility has been rarely reported.

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