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Merck
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OP140

Sigma-Aldrich

Anti-p53 (Ab-12) (Pantropic) Mouse mAb (DO-7)

liquid, clone DO-7, Calbiochem®

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41
클론:
DO-7, monoclonal
application:
종 반응성:
bovine, monkey, human
citations:
11

생물학적 소스

mouse

Quality Level

100

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

DO-7, monoclonal

양식

liquid

미포함

preservative

종 반응성

bovine, monkey, human

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
avoid repeated freeze/thaw cycles

동형

IgG2b

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TP53(7157)

일반 설명

Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen. Recognizes the ~53 kDa wild-type and mutant forms of p53.
Recognizes the ~53 kDa wild-type p53 and mutant p53 protein in SKBR-3 and MDA-231 cells and in colon carcinoma tissue.
This Anti-p53 (Ab-12) (Pantropic) Mouse mAb (DO-7) is validated for use in Frozen Sections, Immunoblotting, IF, IP, Paraffin Sections for the detection of p53 (Ab-12) (Pantropic).

면역원

Epitope: within amino acids 37-45 of p53
recombinant, human p53 expressed in E. coli

애플리케이션



Frozen Sections (1-2 g/ml)
Immunoblotting (1-2 g/ml)
Immunofluorescence (0.5 g/ml)
Immunoprecipitation (2 g/mg lysate)
Paraffin Sections (1-2 g/ml)

포장

Please refer to vial label for lot-specific concentration.

경고

Toxicity: Standard Handling (A)

분석 메모

Positive Control
SKBR-3 or MDA-231 cells or colon carcinoma tissue

기타 정보

Exhibits nuclear staining in tumor cells. Antibody should be titrated for optimal results in individual systems.
Greenblatt, M.S., et al. 1994. Cancer Res.54, 4855.
Lane, D.P. 1992. Nature358, 15.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Jinichi Mori et al.
Neoplasia (New York, N.Y.), 19(3), 185-195 (2017-02-06)
p53 activation by cellular stresses induces the transcription of hundreds of its target genes. To elucidate the entire picture of its downstream pathway, we screened a cDNA microarray dataset of adriamycin-treated HCT116 p53-/- or p53+/+ cells and identified EPSIN 3
Jinichi Mori et al.
Cancer science, 107(3), 298-306 (2016-01-13)
In response to various cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes. However, the full picture of the p53 downstream pathway still remains to be elucidated. Here we identified cystatin C
Yuki Funauchi et al.
Scientific reports, 5, 16497-16497 (2015-11-13)
Accumulation of iron in tissues increases the risk of cancer, but iron regulatory mechanisms in cancer tissues are largely unknown. Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes
Matthew T Balmer et al.
Cancer biology & therapy, 15(8), 1000-1012 (2014-05-08)
The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the

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