MABF2049

Anti-LTBR Antibody, clone 3C8

clone 3C8, from rat

• 동의어(들): Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: 3C8, monoclonal
• application: FACS
• 종 반응성: mouse
• 기술: flow cytometry: suitable

속성

• 생물학적 소스: rat
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 3C8, monoclonal
• 종 반응성: mouse
• 기술: flow cytometry: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_034866.1
• UniProt 수납 번호: P50284
• 배송 상태: ambient
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Ltbr(17000)

설명

일반 설명

Tumor necrosis factor receptor superfamily member 3 (UniProt: P50284; also known as Lymphotoxin-beta receptor, LTBR) is encoded by the Ltbr (also known as Tnfcr, Tnfrsf3) gene (Gene ID: 17000) in murine species. The tumor necrosis factor (TNF) receptor superfamily comprises more than 20 type-I transmembrane proteins. LTBR is a single-pass type I membrane protein that contains 4 TNFR-Cys repeats and serves as a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. LTBR plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kB pathway. The binding of heterotrimeric lymphotoxin to LTBR is shown to induce NF-kB activation and cell death in HT29 adenocarcinoma cells. LTBR activation promotes apoptosis via TRAF3 and TRAF5. It is also reported to play a role in the development of lymphoid organs. Mice deficient in the LTBR gene fail to form lymph nodes and lack NK and NK-T cells. In the adults, LTBR signaling is essential for maintaining the splenic architecture, for the integrity of marginal zones, and for compartmentalization of T and B cells.

특이성

Clone 3C8 detects Tumor necrosis factor receptor superfamily member 3 in NIH3T3 cells.

면역원

LT betaR-Fc decoy protein.

애플리케이션

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Zhu, M., et. al. (2006). J Clin Invest. 116(11):2964-71).

Flow Cytometry Analysis: A representative lot detected LTBR in Flow Cytometry applications (Yi, T., et. al. (2013). Elife. 2:e00757).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Dejardin, E., et. al. (2002). Immunity. 17(4):525-35).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Vondenhoff, M.F., et. al. (2009). J Immunol. 182(9):5439-45).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Yi, T., et. al. (2013). Elife. 2:e00757).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Banks, T.A., et. al. (2005). J Immunol. 174(11):7217-25).

Research Category
Inflammation & Immunology

This rat monoclonal Anti-LTBR, clone 3C8, Cat. No. MABF2049, is tested for use in Flow Cytometry and in functional studies for the detection of Lymphotoxin-beta receptor/LTbeta R.

품질

Evaluated by Flow Cytometry in NIH/3T3 cells.

Flow Cytometry Analysis: 1 µg of this antibody detected LTBR in one million NIH/3T3 cells.

표적 설명

44.95 kDa calculated.

물리적 형태

Format: Purified

Protein G purified

Purified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1