ABT17

Anti-RGS4 Antibody

serum, from rabbit

• 동의어(들): regulator of G-protein signaling 4, regulator of G-protein signalling 4, schizophrenia disorder 9
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: serum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: rat
• 기술: western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NP_058910
• UniProt 수납 번호: P49799
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RGS4(5999)

설명

일반 설명

Regulator of G-protein signaling 4 (RGS4) is a GTPase activating protein belonging to the RGS family. This is a group of proteins known to act as GTPase activating proteins (GAPs), in order to regulate G protein signaling. RGS4 is highly expressed throughout the brain with highest expression observed in the prefrontal cortex, and some expression found in peripheral tissues such as the heart. RGS4 acts as a signal transduction inhibitor by inactivating G protein alpha subunits through the increase of their GTPase activity. Also, RGS4 serves to enhance Gi/o and Gq/11 protein GTPase activity and to expedite the conclusion of GPCR signaling. Various studies indicate a potential role for RGS4 in the regulation of various neurotransmitter systems, including those with putative involvement in schizophrenia. Mutations in the RGS4 gene lead to a lower presence of RGS4, linked to both Schizophrenia and Alzheimer’s symptoms.

면역원

Recombinant protein corresponding to rat RGS4.

애플리케이션

Detect RGS4 using this Anti-RGS4 Antibody validated for use in WB.

Research Category
Cell Structure

Signaling

Research Sub Category
Cytoskeletal Signaling

G-proteins

Western Blot Analysis: 1:1,000 dilution from a representative lot detected RGS4 on 10 µg of recombinant RGS4.

품질

Evaluated by Western Blot in PC12 cell lysate.

Western Blot Analysis: 1:1000 dilution of the antibody detected RGS4 in 10 µg of PC12 cell lysate.

표적 설명

~ 23 kDa MW observed. A non-specific band appears at ~ 12 kDa

물리적 형태

Rabbit polyclonal serum containing 0.05% sodium azide.

Unpurified

저장 및 안정성

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

분석 메모

Control
PC12 cell lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1