869006-M

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

• 동의어(들): Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
• CAS Number: 9002-71-5
• MDL number: MFCD00867077
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human pituitary glands
• Quality Level: 100
• 설명: Merck USA index - 14, 9414
• 무균: non-sterile
• 분석: ≥95% (weight)
• 양식: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 기술: enzyme immunoassay: suitable
• 불순물: ≤0.1% hPRL (weight); ≤0.2% hGH, hFSH (weight); ≤0.3% hLH (weight)
• solubility: 0.05 M PBS: 1 mg/mL
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... TSHB(7252)

설명

일반 설명

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

생화학적/생리학적 작용

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

경고

Toxicity: Standard Handling (A)

단위 정의

1mg/ml in 0.05M PBS

제조 메모

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable