P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

• 동의어(들): L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide
• 실험식(Hill 표기법): C₁₆H₂₂N₆O₄
• CAS Number: 24305-27-9
• Molecular Weight: 362.38
• Beilstein: 770238
• EC Number: 246-143-4
• MDL number: MFCD00038640
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24898185
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 분자량: 362.38
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 기술: activity assay: suitable
• 불순물: 22.6-23.8% Nitrogen; 51.9-54.1% carbon
• solubility: water: 25 mg/mL, cloudy, colorless to faintly yellow
• UniProt 수납 번호: P20396; P21761; P34981
• 저장 온도: −20°C
• SMILES string: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• InChI key: XNSAINXGIQZQOO-SRVKXCTJSA-N
• 유전자 정보: human ... TRH(7200) , TRHR(7201) ; mouse ... Trhr(22045)

설명

Amino Acid Sequence

Glp-His-Pro-NH2

일반 설명

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

애플리케이션

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

생화학적/생리학적 작용

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)