추천 제품
생물학적 소스
human pituitary glands
Quality Level
무균
non-sterile
형태
lyophilized powder
특이 활성도
≥6.2 IU/mg (immunoassay, non-sterile)
저장 조건
(Keep container tightly closed in a dry and well-ventilated place)
기술
cell culture | mammalian: suitable
불순물
HIV-1/HIV-2, tested negative
배송 상태
ambient
저장 온도
−20°C
유전자 정보
human ... TSHB(7252) , TSHR(7253)
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일반 설명
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
애플리케이션
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation. It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.
생화학적/생리학적 작용
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins. In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
포장
Package size based on hormone
물리적 형태
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Impact of light exposure on thyroid-stimulating hormone results using the Siemens Advia Centaur TSH-3Ultra assay
Armer J, et al.
Annals of Clinical Biochemistry, 54(5), 612-615 (2017)
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
J Carretero et al.
Histology and histopathology, 4(1), 71-76 (1989-01-01)
The TSH-producing adenohypohyseal cells of Wistar rats were studied after treatment with orally administered methymazole by the PAP immunocytochemical method. These cells were compared with those of normal animals. The effects of methymazole were different in the females to those
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