T8931

Thyrotropic hormone from bovine pituitary

• 동의어(들): TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
• CAS Number: 9002-71-5
• MDL number: MFCD00166060
• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• 생물학적 소스: bovine pituitary glands
• 형태: powder
• 포장: vial of 100 μg
• 기술: cell culture | mammalian: suitable
• UniProt 수납 번호: P01223; P16473
• 저장 온도: 2-8°C
• 유전자 정보: cow ... TSHB(281552) ; human ... TSHR(7253)

설명

일반 설명

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

애플리케이션

Thyrotropic hormone from bovine pituitary has been used:

• to induce cAMP production in orbital fibroblasts.
• as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
• for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
• for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

생화학적/생리학적 작용

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (¹³¹I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.

Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

품질

Contains phosphate buffer salts

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable