540216

PTP Inhibitor XVIII

The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): PTP Inhibitor XVIII, Protein Tyrosine Phosphatase Inhibitor XIII, 5-( E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII, Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
• 실험식(Hill 표기법): C₁₉H₁₀BrF₆NO₃S
• CAS Number: 1229246-07-4
• Molecular Weight: 526.25
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light yellow
• solubility: DMSO: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC₅₀ = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett.19, 6161.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable