추천 제품
생물학적 소스
human leucocytes
Quality Level
형태
lyophilized powder
특이 활성도
≥60 units/mg protein (Bradford)
분자량
23-30 kDa
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... CTSG(1511)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.
애플리케이션
Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.
생화학적/생리학적 작용
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
단위 정의
One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
물리적 형태
Lyophilized from 0.5 M pyridinium acetate, pH 5.3.
기질
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
A type VII collagen subdomain mutant is thermolabile and shows enhanced proteolytic degradability?Implications for the pathogenesis of recessive dystrophic epidermolysis bullosa?
Windler C, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(1), 52-59 (2017)
Delivery and therapeutic potential of human granzyme B
Kurschus FC and Jenne DE
Immunological Reviews, 235(1), 159-171 (2010)
Structure, function, and control of neutrophil proteinases
Travis J
The American Journal of Medicine, 84(6), 37-42 (1988)
Cathepsin G: roles in antigen presentation and beyond
Burster T, et al.
Molecular Immunology, 47(4), 658-665 (2010)
Cell surface cathepsin G activity differs between human natural killer cell subsets
Penczek A, et al.
Immunology Letters, 179, 80-84 (2016)
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