516561

Pertussis toxin

from Bordetella pertussis, Five distinct bands by SDS-PAGE, liquid, protein endotoxin, Calbiochem

• 동의어(들): Pertussis Toxin, Bordetella pertussis, Glycerol Solution
• CAS Number: 70323-44-3
• MDL number: MFCD00131841
• UNSPSC 코드: 12352200
• NACRES: NA.25

속성

• 제품명: Pertussis Toxin, Bordetella pertussis, Glycerol Solution, Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.
• Quality Level: 200
• 설명: RTECS - XW5883750
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC
• InChI: 1S/C26H52O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28-2/h3-25H2,1-2H3
• InChI key: WOPKHAQDUMDJIY-UHFFFAOYSA-N

설명

일반 설명

A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.

Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

생화학적/생리학적 작용

≤1 ng/ml as determined in a clustering assay using CHO cells line

Primary Target
Guanine nucleotide-binding regulatory proteins

Product does not compete with ATP.

Target IC₅₀: ≤1 ng/ml as determined in a clustering assay using CHO cells line

경고

Toxicity: Toxic (F)

물리적 형태

In 500 mM NaCl, 50 mM Tris, 10 mM glycine, 50% glycerol, pH 7.5.

재구성

A uniform suspension may be achieved by gentle mixing prior to use.

분석 메모

Five distinct bands by SDS-PAGE

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Fryer, M.W. 1992. Neurosci. Lett.146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol.175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol.227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem.267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J.6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap.263, 1479
Kaslow, H.R., et al. 1987. Biochemistry26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun.40, 1198.
Moss, J., et al. 1983. J. Biol. Chem.258, 11879.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2