506101

p21-Activated Kinase Inhibitor, PAK18

The p21-Activated Kinase Inhibitor, PAK18 controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): p21-Activated Kinase Inhibitor, PAK18, H₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO₂H, PAK Inhibitor I
• 실험식(Hill 표기법): C₁₄₆H₂₅₄N₅₈O₃₇
• Molecular Weight: 3413.95
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: lyophilized
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).

A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
PAK (p21-activated kinase)

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable