368055

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
• 실험식(Hill 표기법): C₂₁H₃₄N₄O₁₀
• CAS Number: 1258003-96-1
• Molecular Weight: 502.52
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A potent, reversible inhibitor of granzyme B and caspase-8 (K_i = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

Potent, reversible granzyme B and caspase-8 inhibitor.

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 1 nM against caspase-8

경고

Toxicity: Standard Handling (A)

서열

Ac-Ile-Glu-Thr-Asp-CHO

기타 정보

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable