368050

Granzyme B Inhibitor I

≥95% (HPLC), solid, Granzyme B inhibitor, Calbiochem^®

• 동의어(들): Granzyme B Inhibitor I, Z-AAD-CMK
• 실험식(Hill 표기법): C₁₉H₂₄ClN₃O₇
• Molecular Weight: 441.86
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Granzyme B Inhibitor I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: off-white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).

A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Granzyme B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2

경고

Toxicity: Standard Handling (A)

서열

Z-Ala-Ala-Asp-CH₂Cl

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable