298711

Diethyl Pyrocarbonate

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles.

• 동의어(들): Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC
• 실험식(Hill 표기법): C₆H₁₀O₅
• CAS Number: 1609-47-8
• Molecular Weight: 162.14
• MDL number: MFCD00009106
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (titration)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: clear colorless
• solubility: chloroform: soluble; ethanol: soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3
• InChI key: FFYPMLJYZAEMQB-UHFFFAOYSA-N

설명

일반 설명

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

기타 정보

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): 156.2 °F - closed cup
• Flash Point (°C): 69 °C - closed cup