19-123-M

Staurosporine

Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

• 동의어(들): PKC inhibitor, protein kinase C inhibitor
• UNSPSC 코드: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

속성

• Quality Level: 100
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)

설명

일반 설명

Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.

애플리케이션

Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.

생화학적/생리학적 작용

Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.

품질

Routinely evaluated by Protein Kinase Inhibition Assay

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361d,H413
• 예방조치 성명서: P201 - P202 - P273 - P280 - P308 + P313 - P405
• Hazard Classifications: Aquatic Chronic 4 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable