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Merck
모든 사진(1)

주요 문서

S6942

Sigma-Aldrich

Staurosporine

from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor

동의어(들):

Antibiotic AM-2282

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About This Item

EC Number:
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77

제품명

Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered

Quality Level

무균

0.2 μm filtered

분석

>98% (HPLC)

농도

1 mM in DMSO (100 μg/214 μL)

기술

cell culture | mammalian: suitable

항생제 활성 스펙트럼

fungi

동작 모드

enzyme | inhibits

배송 상태

wet ice

저장 온도

−20°C

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일반 설명

Chemical structure: indol derivative

애플리케이션

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4

생화학적/생리학적 작용

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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문서 라이브러리 방문

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American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
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G Warnes et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(3), 181-191 (2011-01-22)
The standard method of distinguishing apoptotic and oncotic cells has been by microscopic analysis of nuclei and cell membrane morphology. Thus a rapid test for analyzing large numbers of cells in the study of cell necrobiology has not been possible
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The Journal of pharmacology and experimental therapeutics, 364(1), 110-119 (2017-10-19)
Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes
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문서

Drug Transport

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