추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
mouse
기술
ChIP: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Klf2(16598)
일반 설명
Krueppel-like factor 2 (Klf2) is a novel protein belonging to the KLF family of transcription factors, a subfamily of approximately 20 members characterized by their possession of a zinc-finger domain and functioning as transcriptional regulators for cellular differentiation and growth. Klf2 activates transcription through its binding of the beta-globin gene promoter CACCC box. Studies have shown Klf2 to have critical roles in both the function and differentiation of several cell types including; adipocytes, lung cells, T lymphocytes, and monocytes. It has also been newly identified as an endothelial transcription regulator for pro-inflammatory activation, and is a requirement for the migration of smooth muscle cells and normal vessel formation. Shear stress and pro-inflammatory cytokines are considered to be potent inhibitors of Klf2. Expression is primarily observed in lung and spleen tissue, but it has also been found in aortic tissue.
면역원
Epitope: Unknown
GST-fusion protein with histidine-tagged mouse Klf2.
애플리케이션
Chromatin Immunoprecipitation Analysis: 5 µL from a representative lot immunoprecipitated Klf2 from 2 x 10E6 to 1 x 10E7 mouse embryonic stem cells. (Huck Ng, Genome Institute of Singapore.)
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Use Anti-Klf2 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect Klf2 also known as Kruppel-like factor 2 (lung), Lung krueppel-like factor.
품질
Evaluated by Western Blot in mouse embryonic stem cell chromatin extract.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Klf2 in 10 µg of mouse embryonic stem cell chromatin extract.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Klf2 in 10 µg of mouse embryonic stem cell chromatin extract.
표적 설명
~40 kDa observed
물리적 형태
Rabbit polyclonal serum containing 0.05% sodium azide.
Unpurified
저장 및 안정성
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
분석 메모
Control
Mouse embryonic stem cell chromatin extract
Mouse embryonic stem cell chromatin extract
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yuki Hirata et al.
Biomedical research (Tokyo, Japan), 40(2), 67-78 (2019-04-16)
T1R1 and T1R3 are receptors expressed in taste buds that detect L-amino acids. These receptors are also expressed throughout diverse organ systems, such as the digestive system and muscle tissue, and are thought to function as amino acid sensors. The
Klf2 is an essential factor that sustains ground state pluripotency.
Yeo, JC; Jiang, J; Tan, ZY; Yim, GR; Ng, JH; Goke, J; Kraus, P; Liang, H; Gonzales et al.
Cell Stem Cell null
Naoki Okashita et al.
Stem cell reports, 7(6), 1072-1086 (2016-11-22)
Primordial germ cells (PGCs) are specified from epiblast cells in mice. Genes associated with naive pluripotency are repressed in the transition from inner cell mass to epiblast cells, followed by upregulation after PGC specification. However, the molecular mechanisms underlying the
Jinbeom Heo et al.
EMBO molecular medicine, 12(1), e10880-e10880 (2019-11-12)
Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orchestrated pluripotency and cell-cycling in embryonic
Chenfeng Liu et al.
Science advances, 7(41), eabg6262-eabg6262 (2021-10-09)
Molecular pathways controlling emigration of mature thymocytes from thymus to the periphery remain incompletely understood. Here, we show that T cell–specific ablation of glycogen synthase kinase 3 (GSK3) led to severely impaired thymic egress. In the absence of GSK3, β-catenin
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