추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
mouse, human
종 반응성(상동성에 의해 예측)
rat (based on 100% sequence homology)
기술
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... LOX(4015)
일반 설명
Lysyl Oxidase (Protein-lysine 6-oxidase; LOX) is a member of the lysyl oxidase family and a product of the LOX gene. Lysyl oxidase is an extracellular-matrix oxidative enzyme characterized by its C-terminal LOX catalytic domain. In the presence of copper, lysyl oxidase removes amine groups from lysine residues of target substrates which include precursors of collagen and elastin. This deamination reaction produces reactive lysine residues which can then interact with similarly activated species to form covalent cross-links. Lysyl oxidase is found predominantly in the kidney, pancreas, heart, skeletal muscle, and placenta. Defective lysyl oxidase proteins play a role in cutis laxa autosomal recessive type 1 condition. Other studies have also suggested that lysyl oxidase may also be involved in intracellular signaling and may function as a tumor suppressor.
면역원
KLH-conjugated linear peptide corresponding to Lysyl Oxidase (LOX).
애플리케이션
Anti-Lysyl Oxidase (LOX) Antibody is an antibody against Lysyl Oxidase (LOX) for use in Western Blotting, IHC(P).
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Lysyl Oxidase (LOX) in adenocarcinoma cells of human prostate tissues.
품질
Evaluated by Western Blot in NIH/3T3 nuclear extract.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Lysyl Oxidase (LOX) in 10 µg of NIH/3T3 nuclear extract.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Lysyl Oxidase (LOX) in 10 µg of NIH/3T3 nuclear extract.
표적 설명
~46 kDa observed
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller, BW; Morton, JP; Pinese, M; Saturno, G; Jamieson, NB; McGhee, E; Timpson, P; Leach et al.
EMBO Molecular Medicine null
Rolf Schreckenberg et al.
Frontiers in physiology, 8, 556-556 (2017-08-22)
Purpose: According to the current therapeutic guidelines of the WHO physical activity and exercise are recommended as first-line therapy of arterial hypertension. Previous results lead to the conclusion, however, that hearts of spontaneously hypertensive rats (SHR) with established hypertension cannot
Mari Ekman et al.
Laboratory investigation; a journal of technical methods and pathology, 94(5), 557-568 (2014-03-05)
Prior work demonstrated increased levels of hypoxia-inducible factor-1α (HIF-1α) in the bladder following outlet obstruction, associated with bladder growth and fibrosis. Here we hypothesized that HIF induction in outlet obstruction also switches energetic support of contraction from mitochondrial respiration to
Rohit Shetty et al.
Molecular vision, 21, 12-25 (2015-01-17)
Keratoconus (KC) is characterized by progressive vision loss due to corneal thinning and structural abnormalities. It is hypothesized that KC is caused by deregulated collagen levels and collagen fibril-maturating enzyme lysyl oxidase (LOX). Further, it is currently not understood whether
Wenqian Fang et al.
Translational research : the journal of laboratory and clinical medicine, 222, 28-40 (2020-05-22)
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease characterized by fat accumulation and inflammation in liver. Yet, the mechanistic insight and diagnostic and therapeutic options of NASH remain incompletely understood. This study tested the roles of
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