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Merck
모든 사진(3)

Key Documents

L4794

Sigma-Aldrich

Anti-Lysyl Oxidase antibody produced in rabbit

enhanced validation

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

동의어(들):

Lysyl Oxidase Antibody, Lysyl Oxidase Antibody - Anti-Lysyl Oxidase antibody produced in rabbit, Anti-LOX, Anti-Protein lysine 6-oxidase

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen ~50 kDa

종 반응성

human

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

농도

~1 mg/mL

기술

western blot: 1.5-3.0 μg/mL using HEK-293T cells expressing human LOX

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... LOX(4015)
mouse ... Lox(16948) , Lox(24914)

일반 설명

The gene LOX (lysyl oxidase) encodes a copper-dependent amine oxidase that belongs to LOX family of proteins. These proteins contain highly conserved C- terminal mature catalytic domains that include the copper binding site, the lysyl tyrosyl quinine (LTQ) cofactor residues, and the cytokine receptor like (CRL) domain. It is present in both intercellular and intracellular locations.

특이성

Rabbit polyclonal anti-Lysyl Oxidase antibody specifically recognizes human lysyl oxidase (LOX). Detection of the LOX band by immunoblotting is specifically inhibited by the LOX immunizing peptide.

애플리케이션

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

생화학적/생리학적 작용

The gene LOX (lysyl oxidase) encodes an extracellular matrix remodeling enzyme that catalyzes the oxidation of primary amino group of peptidyl lysine to reactive peptidyl aldehydes. It is mainly involved in the oxidation of lysine residues in elastin and collagen, resulting in the formation of covalent cross-linkages, which stabilize these fibrous proteins. It also plays a role in several cellular processes such as developmental regulation, tumor suppression, cell motility, and cellular senescence. It is involved in hypoxia-induced metastasis and serves as a therapeutic target for the treatment of metastases.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Essential Thrombocythemia Characterization: Mutational, Cytokine, and Thrombotic Profiling.
Hernandez-Matias L, et al.
Journal of Hematology & Oncology, 2 (2019)
Noelia Agra et al.
PloS one, 8(6), e66281-e66281 (2013-06-12)
Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate and downregulate target genes, leading to cellular transformation. Thus, identificating
Lysyl oxidase, extracellular matrix remodeling and cancer metastasis.
Xiao Q and Ge G
Cancer Microenvironment, 5, 261-273 (2012)
Lysyl oxidase is essential for hypoxia-induced metastasis.
Erler JT
Nature, 440, 1222-1226 (2006)
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.
Kagan HM and Li W
Journal of Cellular Biochemistry, 88, 660-672 (2003)

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