추천 제품
생물학적 소스
mouse
Quality Level
결합
ALEXA FLUOR™ 647
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
JBW301, monoclonal
종 반응성
human
종 반응성(상동성에 의해 예측)
vertebrates (based on 100% sequence homology)
농도
0.5 mg/mL
기술
immunocytochemistry: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
phosphorylation (pSer139)
유전자 정보
human ... H2AX(3014)
일반 설명
As a member of the histone H2A family, histone H2A.x (H2A.x) is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. H2A.x is involved in the DNA repair of double-strand breakage (DSB) damage on nuclear DNA. After a double strand DNA break, H2A.x is rapidly phosphorylated at serine 139 by ATM kinase and becomes gamma-H2AFX. This phosphorylation step can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. As a part of posttranslational modifications during apoptosis caused by severe DNA damage, high expression of phosphorylated H2A.x is considered as an accurate indicator of apoptosis.
면역원
Linear peptide corresponding to phospho Histone H2A.X (Ser139).
애플리케이션
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
This Anti-phospho Histone H2A.X (Ser139) Antibody, clone JBW301, Alexa Fluor™ 647 is validated for use in ICC for the detection of phospho Histone H2A.X (Ser139).
품질
Evaluated by Immunocytochemistry in untreated and staurosporin treated HeLa cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in staurosporin treated HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in staurosporin treated HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
표적 설명
~17 kDa observed. Refer to Cat. No. 05-636 for observed molecular weight information.
물리적 형태
Protein G Purified
Purified mouse conjugate in buffer containing PBS, 15 mg/ml BSA and 0.1% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
법적 정보
ALEXA FLUOR is a trademark of Life Technologies
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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