M-153

Methotrexate-D₃ solution

100 μg/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₂₀H₁₉N₈O₅D₃
• CAS Number: 432545-63-6
• Molecular Weight: 457.46
• EC Number: 200-659-6
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: certified reference material
• Quality Level: 300
• 형태: liquid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 100 μg/mL in methanol with 0.01N NaOH
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: pharmaceutical (small molecule)
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: [2H]C([2H])([2H])N(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/i1D3
• InChI key: FBOZXECLQNJBKD-FIBGUPNXSA-N

설명

일반 설명

An internal standard suitable for therapeutic drug monitoring analyses of methotrexate patient serum samples by LC-MS/MS. Used in the treatment of cancer and autoimmune diseases, methotrexate is an antimetabolite and antifolate drug monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. The Snap-N-Spike^® solution format allows laboratories to eliminate weighing operations of hazardous substances such as methotrexate, significantly reducing occupational exposure hazards related to handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.

애플리케이션

• Application in leukemia research: Methotrexate-D₃ is utilized as an internal standard in LC-MS/MS analysis to monitor the bioavailability and metabolic pathways of thioguanosine and methylthioinosine in children with acute lymphoblastic leukemia, supporting its use in pediatric oncology and pharmacokinetics studies (Han et al., 2022).


• Enhancement of drug monitoring techniques: Employed in high-throughput MALDI-isotope dilution mass spectrometry, Methotrexate-D₃ allows for the ultrafast and selective quantification of methotrexate in human plasma, proving essential for optimizing therapeutic regimens in cancer treatment (Meesters et al., 2011).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H225,H290,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Met. Corr. 1 - STOT SE 1
• 표적 기관: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup