D-927

Doxepin hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₁₉H₂₂ClNO
• CAS Number: 1229-29-4
• Molecular Weight: 315.84
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: certified reference material
• Quality Level: 300
• 양식: liquid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 1.0 mg/mL in methanol (as free base)
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: clinical testing
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: CN(C)CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
• InChI key: MHNSPTUQQIYJOT-CULRIWENSA-N

설명

일반 설명

Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance and sold under trade names such as Silenor^® and Aponal. This analytical reference standard is appropriate for use as starting material in calibrators or controls for numerous LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pharmaceutical research.

애플리케이션

• Magnetic Particle Spray Mass Spectrometry: This study utilizes advanced analytical techniques, potentially incorporating Doxepin hydrochloride as a standard in mass spectrometry, to improve detection sensitivities for antidepressants and other neuropharmacological agents (Venga Mendes and Figueiredo, 2024).


• Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures: Though primarily about desipramine, the methodologies and findings could be paralleled in studies using Doxepin hydrochloride to understand its effects on neuroinflammation and pain management (Serafini et al., 2024).


• Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: Reviews the mitigation of toxicity from drugs like Doxepin hydrochloride, underscoring the importance of lipid emulsions in treating drug overdoses and adverse effects (Hwang and Sohn, 2024).


• Novel Ti surface coated with PVA hydrogel and chitosan nanoparticles with antibacterial drug release: While focused on surface coatings, the methodology could be adapted for controlled release studies of tricyclic antidepressants like Doxepin hydrochloride in biomedical applications (Carrazco Ávila et al., 2024).


• Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder: This clinical study on Doxepin could relate directly to Doxepin hydrochloride′s use in sleep medicine and psychiatric research, illustrating its efficacy and therapeutic potential (Yu et al., 2023).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Silenor is a registered trademark of Somaxon Pharmaceuticals, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup