D-111

N-Desmethylzopiclone solution

100 μg/mL in acetonitrile, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₁₆H₁₅ClN₆O₃
• CAS Number: 59878-63-6
• Molecular Weight: 374.78
• MDL number: MFCD08063745
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329798670
• NACRES: NA.24

속성

• Grade: certified reference material
• Quality Level: 300
• 양식: liquid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 100 μg/mL in acetonitrile
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: clinical testing
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: ClC(C=N1)=CC=C1N(C2=O)C(OC(N3CCNCC3)=O)C4=C2N=CC=N4
• InChI: 1S/C16H15ClN6O3/c17-10-1-2-11(21-9-10)23-14(24)12-13(20-4-3-19-12)15(23)26-16(25)22-7-5-18-6-8-22/h1-4,9,15,18H,5-8H2
• InChI key: CGSFZSTXVVJLIX-UHFFFAOYSA-N

설명

일반 설명

A certified Snap-N-Spike^® solution suitable as starting material in calibrators or controls in LC/MS or GC/MS n-desmethylzopiclone testing methods for applications such as urine drug testing, clinical toxicology, or forensic analysis. N-desmethylzopiclone is a primary, inactive metabolite of zopiclone in urine and blood. The parent drug, zopiclone, is a non-benzodiazepine hypnotic used in the treatment of insomnia.

애플리케이션

<ul>
<li><strong>Pharmacokinetic study of zopiclone metabolites:</strong> An in-depth examination of pharmacokinetics, focusing on zopiclone and its metabolites, including N-Desmethylzopiclone, to assess their distribution in hair samples post-administration it is used as an additional marker to confirm the intake of zopiclone (Hansen et al., 2020).</li>
<li><strong>Enantioselective analysis after biotransformation:</strong> The study developed a new and rapid method for the enantioselective analysis of N-Desmethylzopiclone, using fungal biotransformation, crucial for understanding metabolic pathways and anxiolytic activity in pharmaceutical research(de Albuquerque et al., 2015).</li>
<li><strong>Validation of analytical methods for forensic application:</strong> A validated LC-MS/MS method for determining zopiclone, N-Desmethylzopiclone, and other related compounds in blood, providing a reliable tool for forensic and clinical toxicology analyses (Nilsson et al., 2015).</li>
<li><strong>Quantitative analysis in urine:</strong> A comprehensive study on the quantitative analysis of zopiclone and its derivatives, including N-Desmethylzopiclone, in urine using LC-MS-MS, supporting drug monitoring and toxicological investigations (Nilsson et al., 2014).</li>
</ul>

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302 + H312 + H332,H319
• 예방조치 성명서: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 35.6 °F - closed cup
• Flash Point (°C): 2.0 °C - closed cup