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Merck
모든 사진(2)

문서

810267P

Avanti

C11 TopFluor Glucosyl Ceramide

Avanti Research - A Croda Brand 810267P, powder

동의어(들):

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-glucosyl-β1-1′-D-erythro-sphingosine

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About This Item

실험식(Hill 표기법):
C48H80N3O8F2
CAS Number:
Molecular Weight:
865.16
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

형태

powder

포장

pkg of 1 × 250 μg (810267P-250ug)

제조업체/상표

Avanti Research - A Croda Brand 810267P

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Glucosyl Ceramide (GlcCer)/cerebroside/galactosylceramide is a neutral, polar lipid. It can be ionized delicately in negative-and positive-ion modes. It is the simplest glycosphingolipids (GSLs), that is present abundantly in the mammalian tissues. GlcCer is produced through glycosylation of Cer with the help of GlcCer synthase (GCS) at the cytosolic leaflet of Golgi apparatus.

애플리케이션

C11 TopFluor Glucosyl Ceramide is suitable to use as a label in the GLM II model and as a component in the usual giant unilamellar vesicle (GUV) lipid mixture (GLM).

생화학적/생리학적 작용

Glucosyl ceramide (GlcCer) plays a major role in the pathways of glycosphingolipid metabolism. It helps to modulate cell physiology. It acts as an intracellular messenger in cell maintenance and regulation.

포장

5 mL Amber Glass Screw Cap Vial (810267P-250ug)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


시험 성적서(COA)

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문서 라이브러리 방문

Characterization of Lipids by Electrospray Ionization Mass Spectrometry, Lipid Analysis
Lipid analysis (2012)
Effect of glucosylceramide on the biophysical properties of fluid membranes
Varela ARP, et al.
Biochimica et Biophysica Acta - Biomembranes, 1828(3), 1122-1130 (2013)
Omid Motabar et al.
Analytical and bioanalytical chemistry, 402(2), 731-739 (2011-10-29)
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide to form ceramide and glucose. A deficiency of lysosomal glucocerebrosidase due to genetic mutations results in Gaucher disease, in which glucosylceramide accumulates in the lysosomes of certain cell types.
Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2
Drucker P, et al.
Test, 288(34), 24764-24776 (2013)

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