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Merck
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Key Documents

780200C

Avanti

16:0 PE MCC

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

동의어(들):

1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C49H86N2O11PNa
CAS Number:
384832-87-5
Molecular Weight:
933.18
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

형태

liquid

포장

pkg of 1 × 2.5 mL (780200C-25mg)

제조업체/상표

Avanti Research™ - A Croda Brand 780200C

농도

10 mg/mL (780200C-25mg)

응용 분야

advanced drug delivery

배송 상태

dry ice

저장 온도

−20°C

일반 설명

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (16:0 PE MCC) is a lipid that comprises phosphoethanolamine linked to two palmitic acid by its phosphate group and to a maleimide moiety through its amino group. The maleimide group is a thiol acceptor and 16:0 PE MCC is a maleimide-based lipidating reagent.

애플리케이션

16:0 PE MCC (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-4-(p-maleimidomethyl)cyclohexane-carboxamide) may be used:
  • in the preparation of liposomes for conjugation with human immune deficiency virus (HIV-1) envelope glycoprotein trimers
  • in the preparation of oligonucleotide-modified vesicles
  • in the functionalization of the flat silicon wafers
  • in lipid vesicle preparation

생화학적/생리학적 작용

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide](1,2-Bis(diphenylphosphino)ethane (DPPE)-MCC) in functionalized liposomes aids in covalent attachment via the maleimide group. It acts as a vehicle in peptide transport studies.

포장

5 mL Clear Glass Sealed Ampule (780200C-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H302,H315,H319,H331,H336,H351,H361d,H372

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

표적 기관

Central nervous system

WGK

WGK 3

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Malin Edvardsson et al.
Analytical chemistry, 81(1), 349-361 (2008-11-28)
A novel setup was recently developed, combining quartz crystal microbalance with dissipation monitoring (QCM-D) and optical reflectometry for measurements on one and the same surface of, for example, biomolecular adlayers and interactions ( Rev. Sci. Instr. 2008 , 79 075107
Xiaoming Zhang et al.
Biochemical and biophysical research communications, 349(3), 920-924 (2006-09-15)
Human serum albumin (HSA) patterns have been successfully fabricated for the deposition of lipid bilayer, 1,2-dimyristoyl-sglycerophosphate (DMPA), by making use of the micro-contact printing (microCP) technique and liposome fusion. Confocal laser scanning microscopy (CLSM) results indicate that lipid bilayer has
K Gradauer et al.
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 872-878 (2013-10-22)
The aim of the present study was the in vivo evaluation of thiomer-coated liposomes for an oral application of peptides. For this purpose, salmon calcitonin was chosen as a model drug and encapsulated within liposomes. Subsequently, the drug loaded liposomes
Sebastian Ols et al.
Cell reports, 30(12), 3964-3971 (2020-03-27)
Although intramuscular (i.m.) administration is the most commonly used route for licensed vaccines, subcutaneous (s.c.) delivery is being explored for several new vaccines under development. Here, we use rhesus macaques, physiologically relevant to humans, to identify the anatomical compartments and

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