907367

Fmoc-L-photo-methionine

≥95%, for peptide synthesis

• 동의어(들): (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid, (S)-2-(Fmoc-amino)-4-(3H-diazirin-3-yl)pentanoic acid, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• 실험식(Hill 표기법): C₂₁H₂₁N₃O₄
• CAS Number: 945859-89-2
• Molecular Weight: 379.41
• MDL number: MFCD31380717
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• 제품명: Fmoc-L-photo-methionine, ≥95%
• 분석: ≥95%
• 양식: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 응용 분야: peptide synthesis
• 작용기: Fmoc
• 저장 온도: −20°C
• SMILES string: N([C@@H](CCC4(N=N4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI key: QKMQUEIDJLPYHS-SFHVURJKSA-N

설명

애플리케이션

Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

기타 정보

Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers ′

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Covalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-Linker

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable