804568

(R,S)-Bode Kinetic Resolution Catalyst

• 동의어(들): (4aR,9aS)-6-Bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one
• 실험식(Hill 표기법): C₁₁H₁₀BrNO₃
• CAS Number: 1394957-71-1
• Molecular Weight: 284.11
• MDL number: MFCD29037020
• UNSPSC 코드: 12352101
• PubChem Substance ID: 329768882
• NACRES: NA.22

속성

• 양식: solution
• Quality Level: 100
• 작용기: bromo; ether
• 저장 온도: 15-25°C
• SMILES string: O=C(CO1)N(O)[C@@]2([H])[C@]1([H])CC3=CC=C(Br)C=C32
• InChI: 1S/C11H10BrNO3/c12-7-2-1-6-3-9-11(8(6)4-7)13(15)10(14)5-16-9/h1-2,4,9,11,15H,3,5H2/t9-,11+/m0/s1
• InChI key: FQXSUQCCAHKURK-GXSJLCMTSA-N

설명

애플리케이션

The following hydroxamic acid catalyst was shown by Bode and coworkers to assist in the kinetic resolution of cyclic amines through acylation of one enantiomer, which can be controlled using either the (R or S)- or (S or R)-Bode Kinetic Resolution Catalyst, both of which are also available through Sigma-Aldrich.
It can also be employed in the preparation of nonracemic piperidines by kinetic resolution using an α-hydroxy-α′, β-unsaturated ketone in the presence of a pyrrolotriazolium salt.

기타 정보

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable