510300
2-Bromo-1,4-naphthoquinone
98%
동의어(들):
2-Bromo-1,4-dihydronaphthalene-1,4-dione, 2-Bromo-1,4-naphthalenedione, 2-Bromo-p-naphthoquinone, 3-Bromo-1,4-naphthoquinone, 3-Bromonaphthoquinone
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C10H5BrO2
CAS Number:
Molecular Weight:
237.05
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
분석
98%
mp
131-133 °C (lit.)
작용기
bromo
ketone
SMILES string
BrC1=CC(=O)c2ccccc2C1=O
InChI
1S/C10H5BrO2/c11-8-5-9(12)6-3-1-2-4-7(6)10(8)13/h1-5H
InChI key
KJOHPBJYGGFYBJ-UHFFFAOYSA-N
일반 설명
2-Bromo-1,4-naphthoquinone (BrQ) is a 1,4-naphthoquinone derivative that can be prepared by the bromination of 1-naphthol using N-bromosuccinimide. Its efficacy as an antifeedant against the cabbage looper, Trichoplusia ni has been evaluated.2 The reaction of BrQ with xanthene under photochemical conditions has been investigated. A report suggests that the replacement of 2-methyl-1,4-naphthoquinone with BrQ enhances its ability to produce hydrogen peroxide which can be employed for cancer treatment.
애플리케이션
2-Bromo-1,4-naphthoquinone may be used in the preparation of:
- benzo[f]indolequinones
- 2-azido-1,4-naphthoquinone
- 2-allyl-3-bromo-1,4-naphthoquinone
- 2-(3-indolyl)-1,4-naphthoquinones
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
The Photochemical Reaction of 1,4-Naphthoquinone Derivatives with Hydrogen Donors.
Maruyama K and Arakawa S.
Bulletin of the Chemical Society of Japan, 47(8), 1960-1966 (1974)
Padmakar A Suryavanshi et al.
Organic & biomolecular chemistry, 8(15), 3426-3436 (2010-06-10)
The CAN-catalyzed three-component between reaction between primary amines, beta-dicarbonyl compounds and naphthoquinones or 2-bromonaphthoquinones afforded, respectively, 5-hydroxybenzo[g]indoles and benzo[f]indole-4,9-diones, the former of which were transformed into tetracyclic azepino[1,2-a]benzo[g]indole systems through a gamma-alkylation/ring-closing metathesis sequence.
Tiago T Guimarães et al.
European journal of medicinal chemistry, 63, 523-530 (2013-03-29)
Continuing our screening program for novel anti-parasite compounds, we synthesized seven 1,4-naphthoquinones coupled to 1,2,3-triazoles, five nor-β-lapachone-based 1,2,3-triazoles and ten α-lapachone-based 1,2,3-triazoles. These and other naphthoquinonoid compounds were evaluated for their activity against promastigote forms of antimony-sensitive and -resistant strains
Stereoselective synthesis of deoxy analogues of the 3C-protease inhibitor thysanone.
Brimble MA and Elliott RJR
Tetrahedron, 58(1), 183-189 (2002)
F S Graciani et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 45(8), 701-710 (2012-05-16)
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen
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