41996

1-Hydroxy-7-azabenzotriazole solution

~0.6 M in DMF, for peptide synthesis

• 동의어(들): 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt
• 실험식(Hill 표기법): C₅H₄N₄O
• CAS Number: 39968-33-7
• Molecular Weight: 136.11
• Beilstein: 1211115
• MDL number: MFCD00210053
• UNSPSC 코드: 12352005
• PubChem Substance ID: 57650093
• NACRES: NA.22

속성

• product name: 1-Hydroxy-7-azabenzotriazole solution, ~0.6 M in DMF
• 형태: liquid
• Quality Level: 100
• 반응 적합성: reaction type: Addition Reactions
• 농도: ~0.6 M in DMF
• 불순물: <1.0% water
• refractive index: n20/D 1.441
• density: 0.978 g/mL at 20 °C
• 응용 분야: peptide synthesis
• SMILES string: On1nnc2cccnc12
• InChI: 1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
• InChI key: FPIRBHDGWMWJEP-UHFFFAOYSA-N

설명

일반 설명

1-Hydroxy-7-azabenzotriazole solution, also known as 3H-[1,2,3]-triazolo[4,5-b]pyridin-3-ol, is a benzotriazolic additive that is commonly used as a coupling reagent for amino acids and peptides. It is also used to minimize epimerization.

애플리케이션

1-Hydroxy-7-azabenzotriazole solution is used as a reagent in the solid-phase synthesis of chiral peptide nucleic acids.

기타 정보

Coupling additive for efficient racemization-free coupling in peptide synthesis; segment coupling.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H226,H312 + H332,H319,H360D
• 예방조치 성명서: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 136.4 °F - closed cup
• Flash Point (°C): 58 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter