253340
3-Quinuclidinol
99%
๋์์ด(๋ค):
1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine
๋ก๊ทธ์ธ์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ ๋ณด๊ธฐ
๋ชจ๋ ์ฌ์ง(2)
About This Item
์ถ์ฒ ์ ํ
Quality Level
๋ถ์
99%
mp
220-223 ยฐC (lit.)
SMILES string
OC1CN2CC[C@H]1CC2
InChI
1S/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H2
InChI key
IVLICPVPXWEGCA-UHFFFAOYSA-N
์ ์ฌํ ์ ํ์ ์ฐพ์ผ์ญ๋๊น? ๋ฐฉ๋ฌธ ์ ํ ๋น๊ต ์๋ด
์ผ๋ฐ ์ค๋ช
(R)-3-Quinuclidinol is a valuable compound for the production of various pharmaceuticals.
์ ํ๋ฆฌ์ผ์ด์
3-Quinuclidinol has been used:
- as chiral building block for many antimuscarinic agents
- in chemoselective ฮฑโiodination of various simple and multi-functionalised acrylic esters via Morita-Baylis-Hillman protocol
- as reagent for cleavage of ฮฒ-keto and vinylogous ฮฒ-keto esters
- as synthon for the preparation of cholinergic receptor ligands and anesthetics
- as catalyst for condensation of methyl vinyl ketone with aldehydes
์ ํธ์ด
Danger
์ ํด ๋ฐ ์ํ ์ฑ๋ช ์
์๋ฐฉ์กฐ์น ์ฑ๋ช ์
Hazard Classifications
Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point (ยฐF)
Not applicable
Flash Point (ยฐC)
Not applicable
๊ฐ์ธ ๋ณดํธ ์ฅ๋น
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
๊ฐ์ฅ ์ต์ ๋ฒ์ ์ค ํ๋๋ฅผ ์ ํํ์ธ์:
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
Selective Cleavage of ?-Keto and Vinylogous ?-Keto Esters by 3-Quinuclidinol.
Synthetic Communications, 5(5), 341-345 (1975)
Synthesis and local anaesthetic activities of 3-(2-alkoxyphenylcarbamoyloxy)chinuclidinium chlorides.
Die Pharmazie, 48(6), 465-466 (1993-06-01)
Khim.-Farm. Zh., 26, 12-12 (1992)
Tetrahedron Letters, 31, 4509-4509 (1990)
Journal of medicinal chemistry, 34(10), 2989-2993 (1991-10-01)
Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By
์์ฌ์ ๊ณผํ์ํ์ ์๋ช ๊ณผํ, ์ฌ๋ฃ ๊ณผํ, ํํ ํฉ์ฑ, ํฌ๋ก๋งํ ๊ทธ๋ํผ, ๋ถ์ ๋ฐ ๊ธฐํ ๋ง์ ์์ญ์ ํฌํจํ ๋ชจ๋ ๊ณผํ ๋ถ์ผ์ ๊ฒฝํ์ด ์์ต๋๋ค..
๊ณ ๊ฐ์ง์ํ์ผ๋ก ์ฐ๋ฝ๋ฐ๋๋๋ค.