216143

Tetrabutylammonium fluoride solution

1.0 M in THF

• 동의어(들): TBAF solution
• Linear Formula: [CH₃(CH₂)₃]₄NF
• CAS Number: 429-41-4
• Molecular Weight: 261.46
• Beilstein: 3762762
• MDL number: MFCD00011747
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24852802
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 200
• 농도: 1.0 M in THF
• 불순물: ~5 wt. % water
• density: 0.903 g/mL at 25 °C
• 작용기: amine
• 저장 온도: 2-8°C
• SMILES string: [F-].CCCC[N+](CCCC)(CCCC)CCCC
• InChI: 1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
• InChI key: FPGGTKZVZWFYPV-UHFFFAOYSA-M

설명

애플리케이션

Reactant for preparation of:

• Triple monoamine reuptake inhibitors as a new generation of antidepressants
• Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions
• Oligoribonucleotides with phosphonate-modified linkages
• Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride
• Conjugated dienoic acid esters using Suzuki coupling reactions
• Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity
• Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors
• Anti-diabetic polyacetylenic glucosides

Tetrabutylammonium fluoride (TBAF) can be used as a reagent:

• For the deprotection of silyl and N-sulfonyl groups.
• In the fluorination reactions.
• To synthesize 2-substituted indoles by cyclization reaction of various 2-ethynylanilines with terminal alkynes using Pd catalyst. It can also be used as an activator in the synthesis of arylated or alkenylated alkynes by the coupling reaction of aryl and alkenyl halides with terminal alkynes in the presence of Pd catalyst.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302,H315,H319,H335,H336,H351,H361fd,H412
• 예방조치 성명서: P210 - P273 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Central nervous system, Respiratory system
• 보충제 위험성: EUH019,EUH032
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 1.4 °F - closed cup
• Flash Point (°C): -17 °C - closed cup