ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
동의어:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
종:
Human ABCB1 (5243), Thale Cress ABCB1 (818265), cow ABCB1 (281585), Horse ABCB1 (100034074), domestic cat ABCB1 (493707), dog ABCB1 (403879), sheep ABCB1 (443367), Domestic Rabbit ABCB1 (100008914), domestic guinea pig Abcb1 (100733532), naked mole-rat Abcb1 (101702843)
UniProtKB ID:
Clone ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- Thale Cress(818265) ABC transporter B family member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Product Number
설명
종
Small Molecule - Antagonist
Antibodies
Product Number
설명
종별 반응성
응용분야
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
종별 반응성
human
응용분야
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Glycoprotein (MDR) antibody, Mouse monoclonal, clone F4, purified from hybridoma cell culture,
종별 반응성
hamster, human
응용분야
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
종별 반응성
hamster, human
응용분야
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Cell Lines
Kits
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Small Molecule - Mixed Agonist/Antagonist
Product Number
설명
종
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
종
mouse, rat, human
esiRNA
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