コンテンツへスキップ
Merck
  • Reinforcer magnitude and rate dependency: evaluation of resistance-to-change mechanisms.

Reinforcer magnitude and rate dependency: evaluation of resistance-to-change mechanisms.

Behavioural pharmacology (2014-08-15)
Jonathan W Pinkston, Brett C Ginsburg, Richard J Lamb
要旨

Under many circumstances, reinforcer magnitude appears to modulate the rate-dependent effects of drugs such that when schedules arrange for relatively larger reinforcer magnitudes rate dependency is attenuated compared with behavior maintained by smaller magnitudes. The current literature on resistance to change suggests that increased reinforcer density strengthens operant behavior, and such strengthening effects appear to extend to the temporal control of behavior. As rate dependency may be understood as a loss of temporal control, the effects of reinforcer magnitude on rate dependency may be due to increased resistance to disruption of temporally controlled behavior. In the present experiments, pigeons earned different magnitudes of grain during signaled components of a multiple FI schedule. Three drugs, clonidine, haloperidol, and morphine, were examined. All three decreased overall rates of key pecking; however, only the effects of clonidine were attenuated as reinforcer magnitude increased. An analysis of within-interval performance found rate-dependent effects for clonidine and morphine; however, these effects were not modulated by reinforcer magnitude. In addition, we included prefeeding and extinction conditions, standard tests used to measure resistance to change. In general, rate-decreasing effects of prefeeding and extinction were attenuated by increasing reinforcer magnitudes. Rate-dependent analyses of prefeeding showed rate-dependency following those tests, but in no case were these effects modulated by reinforcer magnitude. The results suggest that a resistance-to-change interpretation of the effects of reinforcer magnitude on rate dependency is not viable.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
ハロペリドール, powder
Sigma-Aldrich
クロニジン 塩酸塩, solid
USP
ハロペリドール, United States Pharmacopeia (USP) Reference Standard
クロニジン 塩酸塩, European Pharmacopoeia (EP) Reference Standard
ハロペリドール, European Pharmacopoeia (EP) Reference Standard
システム適合性用ハロペリドール, European Pharmacopoeia (EP) Reference Standard
ハロペリドール, European Pharmacopoeia (EP) Reference Standard