- JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.
JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.
Oncotarget (2014-07-09)
Xun Huang, Danni Sun, Qiuming Pan, Weiwei Wen, Yi Chen, Xianliang Xin, Min Huang, Jian Ding, Meiyu Geng
PMID25003327
要旨
Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer.
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Sigma-Aldrich
ドデシル硫酸ナトリウム, BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC)
Supelco
ドデシル硫酸ナトリウム, dust-free pellets, suitable for electrophoresis, for molecular biology, ≥99.0% (GC)
Sigma-Aldrich
ドデシル硫酸ナトリウム, tested according to NF, mixture of sodium alkyl sulfates consisting mainly of sodium dodecyl sulfate
ドデシル硫酸ナトリウム, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
ドデシル硫酸ナトリウム, BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC), free-flowing, Redi-Dri™