コンテンツへスキップ
Merck
  • Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results.

Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results.

Anticancer research (2014-07-31)
Dirk Rades, Amira Bajrovic, Steven E Schild, Christoph Thorns, Ergin Kilic
要旨

Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented. In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and loco-regional control was evaluated up to 10 years following radio-chemotherapy. On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥ 12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥ 12 g/dl (p<0.001). The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
ホルムアルデヒド 溶液, for molecular biology, 36.5-38% in H2O
SAFC
ホルムアルデヒド 溶液, contains 10-15% methanol as stabilizer, 37 wt. % in H2O
Sigma-Aldrich
5-フルオロウラシル, ≥99% (HPLC), powder
Sigma-Aldrich
ホルムアルデヒド 溶液, for molecular biology, BioReagent, ≥36.0% in H2O (T)
Sigma-Aldrich
cis-ジアンミン白金(II) ジクロリド, crystalline
Supelco
ホルムアルデヒド 溶液, stabilized with methanol, ~37 wt. % in H2O, certified reference material
Sigma-Aldrich
ホルムアルデヒド 溶液, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
Sigma-Aldrich
cis-ジアンミン白金(II)ジクロリド, ≥99.9% trace metals basis
Sigma-Aldrich
ホルムアルデヒド 溶液, meets analytical specification of USP, ≥34.5 wt. %
Sigma-Aldrich
クエン酸濃縮液, BioUltra, for molecular biology, 1 M in H2O
Sigma-Aldrich
クエン酸濃縮液, BioReagent, suitable for coagulation assays, 4 % (w/v)
Supelco
クエン酸ナトリウム, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
ホルムアルデヒド 溶液, tested according to Ph. Eur.
Sigma-Aldrich
ホルムアルデヒド 溶液, SAJ first grade, ≥35.0%, contains methanol as stabilizer
Sigma-Aldrich
ホルムアルデヒド 溶液, 10%
Sigma-Aldrich
Fluorouracil, meets USP testing specifications
Sigma-Aldrich
trans-白金(II)ジアンミンジクロリド
USP
5-フルオロウラシル, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
クエン酸 三ナトリウム塩, ≥98% (GC), anhydrous
Sigma-Aldrich
ホルムアルデヒド 溶液, JIS special grade, 36.0-38.0%, contains methanol as stabilizer
Sigma-Aldrich
Formaldehyde-12C solution, 20% in H2O, 99.9 atom % 12C
シスプラチン, European Pharmacopoeia (EP) Reference Standard
USP
trans-白金(II)ジアンミンジクロリド, United States Pharmacopeia (USP) Reference Standard
Supelco
5-フルオロウラシル, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
5-フルオロウラシル, analytical standard
5-フルオロウラシル, European Pharmacopoeia (EP) Reference Standard
trans-白金(II)ジアンミンジクロリド, European Pharmacopoeia (EP) Reference Standard