- Mutational effects depend on ploidy level: all else is not equal.
Mutational effects depend on ploidy level: all else is not equal.
Biology letters (2012-10-12)
Aleeza C Gerstein
PMID23054913
要旨
Ploidy is predicted to influence adaptation directly, yet whether single mutations behave the same in different ploidy backgrounds has not been well studied. It has often been assumed theoretically that aside from dominance, selective parameters do not differ between cells of varying ploidy. Using the budding yeast Saccharomyces cerevisiae, I compared the effect size of 20 adaptive mutations in haploids and homozygous diploids and found, surprisingly, that the same mutations often had a much larger effect in haploids than homozygous diploids. This empirical result demonstrates that it cannot be assumed that mutations will have the same effect in haploids and homozygous diploids.
材料
製品番号
ブランド
製品内容
Sigma-Aldrich
ナイスタチン懸濁液, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture