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  • Identification of promiscuous small molecule activators in high-throughput enzyme activation screens.

Identification of promiscuous small molecule activators in high-throughput enzyme activation screens.

Journal of medicinal chemistry (2008-03-28)
David R Goode, Ryan K Totten, James T Heeres, Paul J Hergenrother
要旨

It is recognized that high-throughput enzyme inhibition screens often return nonspecific inhibitors as "hits". Recently, high-throughput screens for enzyme activators have led to the identification of several compounds with novel and potent biological activity. Here, we show that enzyme activation screens can also uncover compounds that activate multiple enzymes in a nonspecific fashion. Described herein are the general structural features of such compounds and methods to differentiate between specific and general enzyme activation.

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製品番号
ブランド
製品内容

Sigma-Aldrich
スペルミン, ≥97%
Sigma-Aldrich
スペルミン, suitable for cell culture, BioReagent
Sigma-Aldrich
1,2-Bis(3-aminopropylamino)ethane, technical grade, 94%