1623648

Sufentanil citrate

United States Pharmacopeia (USP) Reference Standard

• 別名: N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide citrate, R-33800, Sufentanyl citrate
• 実験式（ヒル表記法）: C₂₂H₃₀N₂O₂S · C₆H₈O₇
• CAS番号: 60561-17-3
• 分子量: 578.67
• MDL番号: MFCD00072116
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: pharmaceutical primary standard
• APIファミリー: sufentanil
• メーカー／製品名: USP
• 薬剤管理: USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• SMILES記法: [s]1c(ccc1)CCN2CCC(CC2)(N(c3ccccc3)C(=O)CC)COC.OC(CC(=O)O)(CC(=O)O)C(=O)O
• InChI: 1S/C22H30N2O2S.C6H8O7/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-10,17H,3,11-16,18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• InChI Key: OJCZPLDERGDQRJ-UHFFFAOYSA-N

詳細

詳細

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

アプリケーション

Sufentanil citrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Sufentanil Citrate Injection

生物化学的／生理学的作用

Sufentanil is a mu-opioid receptor agonist; analgesic; anesthesia adjunct.

Sufentanil is a mu-opioid selective agonist, 10 times more potent than fentanyl, over 1000 times more potent than morphine. Sufentanil citrate is used as an analgesic and anesthesia adjunct. There are some differences in activity and selectivity among the mu-opiate agonist analgesics. Receptor-internalizing agonists like beta-endorphin, methadone, fentanyl, and sufentanil have been found to induce NADH/NADPH-mediated reactive oxygen species (ROS) synthesis via Phospholipase D-dependent signaling pathways whereas agonists like morphine that do not induce receptor endocytosis failed to activate ROS synthesis. In another report meperidine, remifentanil and tramadol were found to interact with alpha(2)-adrenoceptors, whereas sufentanil did not.

アナリシスノート

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

その他情報

Sales restrictions may apply.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300 + H310 + H330
• 注意書き: P260 - P262 - P280 - P301 + P330 + P331 + P310 - P302 + P352 + P310 - P304 + P340 + P310
• 危険有害性の分類: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable